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Patients were not to have been treated with androgens, anabolic steroids,, anadrol toxicity. Within this common core, similar elements can be identified, including a nucleotide-binding P-loop, Switch I and II motifs, and a relay or ?4-helix Kull and Endow 2013. Similar rearrangements in these elements occur in both kinesin and myosin motors as they alternate between open and closed conformations during the catalytic cycle of nucleotide hydrolysis and force production, . Although some of the structural elements in kinesin resemble those identified in myosins, the kinetic cycles of the motor families are distinct. For kinesin-1, ATP binding induces a state that binds tightly to the microtubule, and subsequent ATP hydrolysis allows the formation of a more weakly bound state Fig..
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